Expert Advisers
Dr. Florian Rieder, MD
RXC008 Expert Advisor
Vice Chair and Co-Section Head of Inflammatory Bowel Diseases, Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, OH.
Dr. Rieder is an investigator at the Department of Inflammation and Immunity and a Full Staff at the Department of Gastroenterology, Hepatology and Nutrition at the Cleveland Clinic, Cleveland. His clinical focus is patients with inflammatory bowel diseases (IBD) with a special emphasis on the field of pathogenesis, prediction and therapy of IBD.
Dr. Rieder has published more than 150 articles and book chapters and has been recognized for his expertise as indicated through invitations to the steering committee of the 2nd European Crohn’s and Colitis Organization (ECCO) scientific workshop on ‘Intestinal healing’, group leader of the 4th ECCO scientific workshop on ‘Intestinal fibrosis’, invitations as a full member of the consensus panel of the ECCO guidelines on Crohn’s disease, lead author of the ECCO guidelines on Ulcerative colitis and lead author of the first ECCO clinical consensus on ‘Diagnosis and Management of Intestinal Fibrosis’ as well as multiple international invitations as a speaker, session chair or conference faculty.
Dr. Rieder serves as an abstract reviewer for all major GI conferences, he is/was an associate editor (Clinical and Translational Gastroenterology) and on several editorial boards of medical journals (Journal of Crohn’s and Colitis, Inflammatory Bowel Diseases, Gastroenterology and Hepatology, Fibrogenesis and Tissue Repair, American Journal of Physiology Gastrointestinal and Liver Physiology). He is proud of his significant ties to the ECCO, which he served as the chair of Y-ECCO, member of the ECCO operational board and member of the scientific committee. He was chair of REACH-IBD and is currently co-chair of the Professional Education Committee of the Crohn’s and Colitis Foundation.
Dr. Reider leads the STAR consortium, a group seeking to identify and develop novel biomarkers and endpoints to help establish effective therapeutics for Crohn’s disease patients with fibrosis.
Dr. Gisli Jenkins
Fibrosis Expert Adviser
Professor of Thoracic Medicine, National Heart and Lung Institute, Imperial College London
Dr Jenkins’ research focuses on the mechanism by which injury leads to scarring in the lung. Lung scarring is the central process leading to disability and death in people with Idiopathic Pulmonary Fibrosis, and also occurs in diseases such as chronic asthma where it promotes airway remodelling and impaired lung function. Following injury to the lung various cells activate TGFb via integrins in a spatially restricted manner. The activated TGFb then leads to cellular changes that promote the development of scarring. Much of the work is focused on two integrins in two cell types within the lung.
Professor Toby Maher, M.D., Ph.D
RXC007 Phase 2 Chief Investigator for Redx
Professor of Clinical Medicine at Keck Medicine of USC.
Professor Maher is currently a Professor of Clinical Medicine and Director of the ILD program at Keck Medicine of USC, one of only two university-based medical systems in the Los Angeles area. Encompassing academic excellence, world-class research and state-of-the-art clinical care.
Prior to this Professor Maher previously worked as Consultant Respiratory Physician on the Interstitial Lung Disease Unit at the Royal Brompton Hospital. He remains a Professor of Interstitial Lung Disease at Imperial College, London.
Professor Philip Molyneaux
RXC007 Phase 2 Chief Investigator for Redx
Asthma+Lung UK Chair of Respiratory Research and director of the NIHR Cardiorespiratory Clinical Research Facility at the Royal Brompton Hospital.
Dr Philip Molyneaux qualified at Guy’s, King’s and St Thomas’ School of Medicine in 2004, where he completed an intercalated BSc. in Molecular Genetics. He undertook his senior house officer training at Guy’s and St Thomas’ followed by a National Institute for Health Research (NIHR) Academic Clinical Fellow position in respiratory medicine at Imperial College, London.
He completed a PhD studying the role of infection in the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF) at Imperial College. He was subsequently awarded the Action for Pulmonary Fibrosis Mike Bray Fellowship which enabled him to establish an active clinical and translational research program that oversees a team of basic scientists and clinical trial research staff.
Dr. John C Davis, Jr, MD, MPH, MS, FACP, FACR
Medical Adviser – Fibrotic Diseases
Dr. Davis currently serves as a member of the board of directors and chair of the science committee at Sonoma Biotherapeutics in San Francisco and Seattle and president of Norte Health Consulting, LLC in Cambridge, MA. He also was most recently the interim chief medical officer at Sonoma Bio. He continues to serve as a strategic advisor and scientific advisory board member of several companies including Human Immunology Biosciences (HiBio), Oak Hill Bio, Graphite Bio, and multiple earlier companies and biotech-focused venture capital groups. He previously served on the board of directors for Rheos Medicines and the scientific advisory board at Magenta Therapeutics.
He served as Head of Research and Development and Chief Medical Officer at Magenta Therapeutics in Cambridge, MA. In this role he was instrumental in driving the company forward as Magenta offered its IPO and becoming a clinical stage company. He has continued to build and grow the research and development organization across multiple platforms and multiple therapeutic areas including gene therapy, rare metabolic diseases, and blood cancers. Prior to joining Magenta, Dr. Davis was Senior Vice President and Head of Early Clinical Development at Pfizer Inc. where he oversaw multiple functional groups across global sites. In his role at Pfizer, he was responsible for bringing 17 groups under one organization across multiple therapeutic areas of focus on a global basis. Prior to his role at Pfizer, Dr. Davis served as Vice President and Global Therapeutic Area Head of Immunology across research and marketed products at Baxalta which was acquired by Shire. Dr. Davis held multiple leadership roles at Genentech and ultimately was Head of the Inflammation and Cardiovascular/Metabolism Group in the Early Clinical Development Group at Genentech.
Dr. Davis spent many years on faculty at The University of California San Francisco leading international clinical research programs in autoimmune disease and became Professor of Clinical Medicine. He continues to see patients, teach, and serve as volunteer faculty at the Boston VA Medical Center. He is a Fellow of The American College of Physicians and The American College of Rheumatology. He has authored over 120 publications and book chapters and has help international leadership positions in his areas of research focus in autoimmune disease.
Dr. Davis earned an MD from the University of Maryland summa cum laude. Dr. Davis trained in Internal Medicine and Rheumatology at The University of California San Francisco. He continued training in clinical research and rheumatology at The National Institutes of Health NIAMS Intramural Program. He holds a Masters of Public Health Degree in Epidemiology from the University of California Berkeley, and a Master of Science Degree in Anatomy from the University of Maryland School of Medicine.