GI-targeted ROCK inhibitor
Our GI-targeted ROCK programme aims to address this high unmet need in the treatment of Crohn’s disease-associated fibrosis
Figure 1: Reduction in collagen in a murine model of Crohn’s fibrosis. Increase of collagen staining shown in blue in the DSS-treated animals. GI-targeted ROCK inhibitor reduces production of collagen seen as a reduction in blue (trichrome) staining.