RXC008 (GI-targeted ROCK inhibitor)

Potential first-in-class treatment for fibrostenotic Crohn’s Disease

Currently in pre-IND stage

Target/Product

Research

Preclinical

Phase 1

Phase 2

Phase 3

Upcoming Milestones

Discovery Engine

GI-targeted ROCK inhibitor
(RXC008)

Fibrostenotic Crohn’s Disease

Phase 1 study start – end 2023

Crohn’s disease affects 1.5m* people globally and >70,000 new cases are diagnosed each year. Up to 50% of patients** with Crohn’s disease can develop significant fibrosis and stricture formation within ten years after diagnosis; this fibrosis associated with Crohn’s disease is known as fibrostenotic Crohn’s disease.

The current management of fibrotic strictures of the GI tract is primarily surgical as no drugs are specifically approved for fibrosis, which can progress despite intervention with anti-inflammatory therapies.

Relapse rate post surgical intervention is high with >50% patients requiring further surgery within 10 years, many within 12 months. Consequently, patients suffer progressive loss of GI function and repeated resections can lead to major health complications such as short bowel syndrome.

RXC008 is designed to work specifically at the site of fibrosis in the GI tract and to degrade quickly, if absorbed into the bloodstream, through enzyme-mediated metabolism. Preclinical data from Redx’s GI-targeted ROCK inhibitor research project shows strong anti-fibrotic therapeutic effects in multiple animal models of inflammatory bowel disease.

The Company plans to initiate a Phase 1 study with RXC008 at the end of 2023.

Refs: *GlobalData Crohn’s Disease Dynamic Market Forecast to 2026 report; **Rieder, 2013

Fibrostenotic Crohn’s Disease: A Clear Patient Population with Very High Unmet Need

Figure 1: Up to 50% of patients with Crohn’s disease can develop significant fibrosis and stricture formation within ten years after diagnosis

Surgery is the Only Current Treatment Option for Fibrostenotic Crohn’s Disease

Figure 2: Current management of fibrotic strictures of the GI tract is primarily surgical as no drugs are specifically approved for fibrosis

Programme summary

RXC008 (GI-targeted ROCK inhibitor)

Target

GI-targeted ROCK1/2 inhibitor

Status

pre-IND stage

Indications

Fibrostenotic Crohn’s Disease

Future development

2023

Phase 1 start – end 2023