Target/Product
Primary Focus
Research
Pre-clinical (CTA/ IND enabling)
Clinical (Phase 1)
Milestone Date

Combination with PD-1 / PD-L1 in solid tumor (colorectal cancer)

Phase 1 completion – 1H2020

Preclinical development 1H2019

Preclinical development 1H2019

Validated targets (SHP2, AZ collaboration and undisclosed targets)

Lead Optimisation 2018-2020; Development candidates <36 months

Target/Product
Primary Focus
Milestone Date

Combination with PD-1 / PD-L1 in solid tumor (colorectal cancer)

Phase 1 completion – 1H2020

Research
Pre-clinical (CTA/ IND enabling)
Clinical (Phase 1)
Target/Product
Primary Focus
Milestone Date

Preclinical development 1H2019

Research
Pre-clinical (CTA/ IND enabling)
Clinical (Phase 1)
Target/Product
Primary Focus
Milestone Date

Pre clinical 2019 First in man 2020

Research
Pre-clinical (CTA/ IND enabling)
Clinical (Phase 1)
Target/Product
Primary Focus
Milestone Date

Preclinical development 1H2019

Research
Pre-clinical (CTA/ IND enabling)
Clinical (Phase 1)
Target/Product
Primary Focus
Milestone Date

Validated targets (SHP2, AZ collaboration and undisclosed targets)

Lead Optimisation 2018-2020; Development candidates <36 months

Research
Pre-clinical (CTA/ IND enabling)
Clinical (Phase 1)