Our Pipeline

Robust Pipeline Focused on Advancing ROCK Inhibitor Portfolio

Our Pipeline

Target/Product

Indications

Research

Preclinical

Phase 1

Phase 2

Upcoming Milestones / Rights

ROCK Portfolio

Idiopathic pulmonary fibrosis (IPF)

Phase 2a topline data
2024

ROCK2 Selective Inhibitor
zelasudil (RXC007)

Pancreatic cancer

Phase 1b commencement –
2025

Fibrostenotic Crohn’s Disease

Phase 1 healthy volunteer data
2024

Portfolio

Wnt-ligand driven Gl-tumours – combination

Report Data – H1 2024

Potential partnership

Pan-RAF Inhibitor
(JZP815)

Oncology

Porcupine Inhibitor
(RXC006/AZD5055)

Undisclosed non oncology

Discoidin Domain Receptor (DDR) Inhibitor
(RXC009)

Fibrosis, cancer-associated fibrosis

IND / CTA Submission – 2025

KRAS Inhibitors
(G12D selective and pan-KRAS)

Oncology

Wholly Owned
Partnered
GI: Gastrointestinal; IND: Investigational new drug application; MSS mCRC: Microsatellite-Stable Metastatic Colorectal Cancer; RAF: Rapidly accelerated fibrosarcoma; ROCK: Rho associated protein kinase; cGvHD: Chronic Graft Versus Host Disease

ROCK Portfolio
Phase 2

Idiopathic pulmonary fibrosis (IPF)

UPCOMING MILESTONES / RIGHTS

Phase 2a topline data
2024

ROCK2 Selective Inhibitor
zelasudil (RXC007)

Preclinical

Pancreatic cancer

UPCOMING MILESTONES / RIGHTS

Phase 1b commencement –
2025

Phase 1

Fibrostenotic Crohn’s Disease

UPCOMING MILESTONES / RIGHTS

Phase 1 healthy volunteer data
2024

Portfolio
Phase 2

Wnt-ligand driven Gl-tumours – combination

UPCOMING MILESTONES / RIGHTS

Report Data – H1 2024

Potential partnership

Pan-RAF Inhibitor
(JZP815)

Phase 1

Oncology

Porcupine Inhibitor
(RXC006/AZD5055)

Phase 1

Undisclosed non oncology

Discoidin Domain Receptor (DDR) Inhibitor
(RXC009)

Preclinical

Fibrosis, cancer-associated fibrosis

UPCOMING MILESTONES / RIGHTS

IND / CTA Submission – 2025

KRAS Inhibitors
(G12D selective and pan-KRAS)

Research

Oncology

Wholly Owned
Partnered
GI: Gastrointestinal; IND: Investigational new drug application; MSS mCRC: Microsatellite-Stable Metastatic Colorectal Cancer; RAF: Rapidly accelerated fibrosarcoma; ROCK: Rho associated protein kinase; cGvHD: Chronic Graft Versus Host Disease